Tap a large, proven market with Caricaya premix for a successful dietary supplement product line extension. Offier it under a white label to grow even faster.

Garden cress seed powder.  Food supplement capsules.  Caricaya capsules.

Extend your product line into stomach acid control to grow profits

Extend your product line into stomach acid control to grow profits

Extend your product line into stomach acid control to grow profitsExtend your product line into stomach acid control to grow profitsExtend your product line into stomach acid control to grow profits

Consumers are concerned about taking proton pump inhibitors and ranitidine for heartburn after negative news headlines.  

New Herbal Supplement Premix for Leading Brands

Market a new supplement that makes eating enjoyable again without drugs

Digestive health is a concern and quality of life issue for many consumers.  We all like to eat sauces and foods that don't always agree with our stomachs.  Occasional heartburn and indigestion are the uncomfortable results that can make getting to sleep difficult.  It's a great product line extension.


Caricaya™ is a proprietary new dietary supplement premix designed to help those with occasional heartburn and indigestion. It has two modes of action for a wider market and higher reliability.

Taming tomato sauce & other heartburn triggers with Caricaya before meals and bed

Adding Caricaya™ to a diet builds resiliency so that users may again eat foods which previously triggered unpleasant occasional heartburn.  Trigger foods include : tacos, pizza, onions, peppers, tomatoes, citrus, mint, chocolate, coffee, wine, soda.  Smoking can also trigger occasional heartburn.  Your new Caricaya-based heartburn product line extension is a strategy for sales growth.

Risks of Proton Pump Inhibitors & Ranitidine

gell caps in a white bottle; proton-pump inhibitor OTC and prescription drugs.

Disturbing New Research on PPI Drug Side Effects

It seems like every week there are new reports of harmful side-effects of popular heartburn drugs that are proton pump inhibitors (PPIs).  They are prescription and over-the counter drugs widely used to treat GERDs, heartburn and ulcers.  Not only do PPIs have negative side-effects, but they also do not work for up to 25% of the population.


Increased Mortality for PPI Users


A recent study found that "people who take PPIs for about a year have about a 25% higher risk  of death,' says Al-Aly, MD, who's also an assistant professor of medicine at  Washington University School of Medicine in St. Louis.

"Because millions of people take PPIs regularly, that 25% chance could translate into thousands of deaths a year, Al-Aly said.'" 


Caricaya now gives your customers an alternative to PPIs and their potential dangers for relief from occasional heartburn.  Source: WebMD


"Taking PPIs is associated with a small excess of cause specific mortality including death due to cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer."


"Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study". BMJ. (formerly British Medical Journal), 365: l1580. doi:10.1136/bmj.l1580. ISSN 0959-8138. PMC 6538974. PMID 31147311, Xie Y, Bowe B, Yan Y, Xian H, Li T, Al-Aly Z (30 May 2019).  Washington University School of Medicine (30 May 2019).


Increaesed Risk of Gastric Cancer from PPIs


Cheung KS, Chan EW, Wong AYS, et al. (2018) showed that even after H. pylori eradication, long-term PPI use is still associated with an increased risk of gastric cancer by more than twofold. Hence, "long-term PPIs should be used judiciously after considering individual’s risk–benefit profile, particularly among those with history of H. pylori infection."


"Further well-designed prospective studies are warranted to confirm the potential role of PPIs in gastric cancer according to baseline gastric histology and its interaction with other chemopreventive agents like aspirin, statins and metformin."  Cheung, Ka Shing; Leung, Wai K. (January 2019). "Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence". Therapeutic Advances in Gastroenterology. 12: 175628481983451.


Increased Risk of Bone Fractures from PPIs


High dose or long-term use of PPIs carries a possible increased risk of bone fractures which was not found with short-term, low dose use; the FDA included a warning regarding this on PPI drug labels in 2010.  "FDA Drug Safety Communication: Possible increased risk of fractures of the hip, wrist, and spine with the use of proton pump inhibitors", US Food and Drug Administration (FDA). 23 March 2011. Retrieved 23 August 2015.


Other Adverse Effects of PPIs


Common adverse effects of PPIs include headache, nausea, diarrhea, abdominal pain, fatigue, and dizziness.  Infrequent adverse effects include rash, itch, flatulence, constipation, anxiety, and depression according to Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN 0-9757919-2-3


Low levels of magnesium can be found in people on PPI therapy.  Corleto VD, Festa S, Di Giulio E, Annibale B (February 2014). "Proton pump inhibitor therapy and potential long-term harm". Current Opinion in Endocrinology, Diabetes and Obesity. 21 (1): 3–8.

Ranitidine Recall

"These histamine-2 blocker  heartburn medicines are being recalled because they may contain unacceptable levels of N-nitrosodimethylamine (NDMA) a suspected human carcinogen.  FDA has advised companies to recall their ranitidine if testing shows levels of NDMA above the acceptable daily intake (96 nanograms per day or 0.32 parts per million for ranitidine).  Feb 3, 2020"


FDA Updates and Press Announcements on NDMA in Zantac ...


 

Timely Natural Solution to Occasional Heartburn

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Caricaya™ Herbal Supplement with Zinc

Caricaya™ supplement premix is a all-natural blend of vegetable seed powder and a mineral taken before meals and bedtime to mitigate the symptoms occasional heartburn and indigestion.   It's a great way to extend your product line and grow the brand.


Benzyl glucosinolate, one of the two active ingredients in Caricaya, is found in several cruniferous vegetables and we have chosen the source most naturally concentrated so our capsules are as small as possible.  Caricaya is not an extract, so no chemicals are used in its manufacture.


Cruciferous vegetables include broccoli, cauliflower, cabbage, kale, bok  choy, arugula, Brussels sprouts, collards, garden cress, watercress and radishes.  The plant family is Brassicaceae or Cruciferae  is a medium-sized and economically important family of flowering plants commonly known as the mustards, the crucifers, or the cabbage family. Glucosinolates are also called mustard oil glycosides

Quicker Dose Ajustment Appreciated by Users

You can control your dose of the actives in Caricaya meal by meal so that your stomach acid does not fall too low--we all need some to digest our food--or get too high.   It can take up to two weeks to adjust the dose of PPIs, which is a long time if you are not feeling well.  


The phytochemical in Caricaya was studied by our co-founder, Tushar Ray, PhD over 45 years ago while he was working on his doctoral thesis and he published a paper on his work.   He specialized in the biochemistry of stomach lining cells.


Dr. Ray learned that it works directly on the stomach lining and is not permanent  unlike proton-pump inhibitors (PPIs) which shut down the cell-wall channels through which acid leaves the cells where it is produced for the life of most cells of the stomach lining (about 2 weeks).  Caricaya supplement at the recommended dose works from the inside of the stomach and not from the blood-stream side like PPIs and other drugs.  


Phytochemicals are chemicals of plant origin. Phytochemicals (from Greek phyto, meaning "plant") are chemicals produced by plants  through primary or secondary metabolism. They generally have biological  activity in the plant host and play a role in plant growth or defense against competitors, pathogens, or predators.(1)


(1) Phytochemical- Wickipedia,  https://en.m.wikipedia.org › wiki › Phytochemical

How long does glucosinolate stay in the body?

A published 1977 study found that dogs and rats excreted 99.5% and 98% of a oral dose of BiTC after 3 days, on average (1).  This indicates that most oral dosed BiTC is out of the bodies of mammals rather quickly.   Glucosinolate mechanical shredding and hydrating leads to phytochemical including  BITC.  "The metabolism of benzyl isothiocyanate and its cysteine conjugate" by G Brüsewitz, B D Cameron, L F Chasseaud, K Görler, D R Hawkins, H Koch, W H Mennicke, Biochemical Journal, Jan 1977, 162 (1) 99-107; DOI: 10.1042/bj1620099 



Special Knowhow Behind Caricaya

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Protecting Potency Requires Higher Quality Inputs; Premix Reduces Risk of Rejected Batchs for Brand

Special handling and processing is required to keep the active incredients of Caricaya potent and quickly bioavailable.  They include is a volitile and complex ingredient.  Many methods to reduce bacterial, yeast and mold counts in herbs cannot be used for Caricaya.  This means significanly higher risk of costly rejected batches of raw or processed materials is covered by RayIsles when you buy our premix.  


Years of research and development by RayIsles was needed to optimize the manufacture of Caricaya.  Many failures along the way even with a great scientific team.   Unlike drugs, this dietary supplement works by coating the inside of the stomach instead of from the bloodstream. 

US Patent-Pending

The significant investment, long development process and many experiments done by the RayIsles scientific team created novel innovations and is being protected by a pending US patent and proprietary know-how kept as trade secrets.  Patents run for 17 years but trade secrets have no expiration date.  Caricaya premix makes expanding your product line into this market faster and less risky.